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PMK Powder CAS 28578-16-7 Safe Delivery With Stock Pharmaceutical Intermediates

2024-07-12

CAS No. 28578-16-7

Chemical Name:: PMK ethyl glycidate

Synonyms: GLYCIDATE;ethyl 3-(1,3-benzodioxol-5-yl)-2-methyloxirane-2-carboxylate;Pmk Glycidate Oil;3,4-MDP-2-P intermediate;ethyl 3-(benzo[d][1,3]dioxol-5-yl)-2-methyloxirane-2-carboxylate;2-Oxiranecarboxylicacid, 3-(1,3-benzodioxol-5-yl)-2-Methyl-, ethyl ester;cheap 3,4-MDP-2P ethyl ester;3-(1,3-benzodioxol-5-yl)-2-Methyl-;PMK BMK;New PMK

CBNumber:: CB22731285

Molecular Formula:: C13H14O5

Molecular Weight:: 250.25

MDL Number:: MFCD30478653

PMK ethyl glycidate Properties

Boiling point	327.8±42.0 °C(Predicted)
Density	1.302±0.06 g/cm3(Predicted)
solubility	DMF: 15 mg/ml; DMSO: 30 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 1 mg/ml
InChI	InChI=1S/C13H14O5/c1-3-15-12(14)13(2)11(18-13)8-4-5-9-10(6-8)17-7-16-9/h4-6,11H,3,7H2,1-2H3
InChIKey	BRILFEZHPXQINW-UHFFFAOYSA-N
SMILES	O1C(C2=CC=C3OCOC3=C2)C1(C)C(OCC)=O

PMK ethyl glycidate Chemical Properties,Uses,Production

Description

PMK ethyl glycidate is an analytical reference standard categorized as a precursor in the synthesis of methylenedioxy phenethylamines and amphetamines, including 3,4-MDMA. This product is intended for research and forensic applications.

Uses

NSC 195099 can be used as an analytical reference standard.

Application

PMK methyl glycidate is applied as immediate precursors of 3,4-methylenedioxymethamphetamine.

Synthesis

To a solution of piperonal (1, 3.00 g, 19.9 mmol) in CH2Cl2 (100 mL) was added (carbethoxyethylidene)triphenylphosphorane (2,14.5 g, 40.0 mmol), and the reaction mixture was stirred for 24 h at room temperature. The mixture was then concentrated at reduced pressure, and the residue was purified by flash column chromatography on silica gel (hexanes/EtOAc,10:1) to afford olefin 3 (4.45 g, 95%) as a colorless oil: 1H NMR (400 MHz, CDCl3) d 7.58 (s, 1H), 6.92 (d, J = 1.7 Hz, 1H), 6.90 (dd, J = 7.9, 1.7 Hz, 1H), 6.82 (d, J = 8.0 Hz, 1H), 5.97 (s, 2H), 4.24 (q, J = 7.1 Hz, 2H), 2.10 (d, J = 1.6 Hz, 3H),1.33 (t, J = 7.1 Hz, 3H); 13C NMR (100 MHz, CDCl3) d 168.7,147.6, 138.3, 129.9, 126.9, 124.6, 109.5, 108.2, 101.2, 60.7, 14.3,1 4.0; IR (ATR, cm-1): 2981, 2902,1698, 1628, 1502, 1489,1442, 1258, 1224; HRMS (EI) m/z calcd for C13H14O4 (M+) 234.0892, found 234.0895.
latest company case about PMK Powder CAS 28578-16-7 Safe Delivery With Stock Pharmaceutical Intermediates 0 Fig The synthetic step of PMK ethyl glycidate

PMK ethyl glycidate Preparation Products And Raw materials

Raw materials

ethyl (±)-2-bromopropionate Ethyl 2-chloropropionate

PMK ethyl glycidate: Synthesis and Application
PMK ethyl glycidate can be used as intermediate in organic synthesis.